Aubameyang missed their first Group C fixture against Comoros on Monday after testing positive for COVID-19.
But the Gabonese federation announced that their captain along with Axel Meye and Nice’s Mario Lemina will also be sidelined for Friday’s game at the Ahmadou Ahidjo Stadium.
All three were diagnosed with COVID-19 recently and latest medical examinations showed they are dealing with minor heart problems as a result of the illness.
The Gabonese Federation tweeted: “According to the CAF medical commission, the players Pierre Emerick Aubameyang, Axel Meye and Mario Lemina, just out of Covid, cannot take part in this match.
“The examinations would show cardiac lesions. CAF did not want to take any risks.”